Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)

Neutrophil proteinases released at sites of inflammation can affect tissue function by either activating or disarming signal transduction mediated by proteinase-activated receptors (PARs). Because PAR1 is expressed at sites where abundant neutrophil infiltration occurs, we hypothesized that neutroph...

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Detalhes bibliográficos
Main Authors: Mihara, Koichiro, Ramachandran, Rithwik, Renaux, Bernard, Saifeddine, Mahmoud, Hollenberg, Morley D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829148/
https://ncbi.nlm.nih.gov/pubmed/24052258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.483123
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