Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR(2))

Human neutrophil proteinases (elastase, proteinase-3, and cathepsin-G) are released at sites of acute inflammation. We hypothesized that these inflammation-associated proteinases can affect cell signaling by targeting proteinase-activated receptor-2 (PAR(2)). The PAR family of G protein-coupled rece...

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Main Authors: Ramachandran, Rithwik, Mihara, Koichiro, Chung, Hyunjae, Renaux, Bernard, Lau, Chang S., Muruve, Daniel A., DeFea, Kathryn A., Bouvier, Michel, Hollenberg, Morley D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137039/
https://ncbi.nlm.nih.gov/pubmed/21576245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.201988
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