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Dual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism

[Image: see text] Negative allosteric modulators (NAMs) of the human calcium-sensing receptor (CaSR) have previously failed to show efficacy in human osteoporosis clinical trials, but there is now significant interest in repurposing these drugs for hypocalcemic disorders and inflammatory lung diseas...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Pharmacol Transl Sci
Prif Awduron: Gregory, Karen J., Kufareva, Irina, Keller, Andrew N., Khajehali, Elham, Mun, Hee-Chang, Goolam, Mahvash A., Mason, Rebecca S., Capuano, Ben, Conigrave, Arthur D., Christopoulos, Arthur, Leach, Katie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2018
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7089027/
https://ncbi.nlm.nih.gov/pubmed/32219206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.8b00021
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