Dual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism

[Image: see text] Negative allosteric modulators (NAMs) of the human calcium-sensing receptor (CaSR) have previously failed to show efficacy in human osteoporosis clinical trials, but there is now significant interest in repurposing these drugs for hypocalcemic disorders and inflammatory lung diseas...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Gregory, Karen J., Kufareva, Irina, Keller, Andrew N., Khajehali, Elham, Mun, Hee-Chang, Goolam, Mahvash A., Mason, Rebecca S., Capuano, Ben, Conigrave, Arthur D., Christopoulos, Arthur, Leach, Katie
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7089027/
https://ncbi.nlm.nih.gov/pubmed/32219206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.8b00021
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