Dual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism

[Image: see text] Negative allosteric modulators (NAMs) of the human calcium-sensing receptor (CaSR) have previously failed to show efficacy in human osteoporosis clinical trials, but there is now significant interest in repurposing these drugs for hypocalcemic disorders and inflammatory lung diseas...

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Bibliografiset tiedot
Julkaisussa:ACS Pharmacol Transl Sci
Päätekijät: Gregory, Karen J., Kufareva, Irina, Keller, Andrew N., Khajehali, Elham, Mun, Hee-Chang, Goolam, Mahvash A., Mason, Rebecca S., Capuano, Ben, Conigrave, Arthur D., Christopoulos, Arthur, Leach, Katie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2018
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7089027/
https://ncbi.nlm.nih.gov/pubmed/32219206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.8b00021
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