Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms

Calcium sensing receptor (CaSR) positive allosteric modulators (PAMs) are therapeutically important. However, few are approved for clinical use, in part due to complexities in assessing allostery at a receptor where the endogenous agonist (extracellular calcium) is present in all biologic fluids. Su...

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Publicado no:Mol Pharmacol
Main Authors: Keller, Andrew N., Kufareva, Irina, Josephs, Tracy M., Diao, Jiayin, Mai, Vyvyan T., Conigrave, Arthur D., Christopoulos, Arthur, Gregory, Karen J., Leach, Katie
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941188/
https://ncbi.nlm.nih.gov/pubmed/29636377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112086
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