Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain

BACKGROUND AND PURPOSE: Negative allosteric modulators (NAMs) that target the calcium‐sensing receptor (CaS receptor) were originally developed for the treatment of osteoporosis by stimulating the release of endogenous parathyroid hormone, but failed in human clinical trials. Several chemically and...

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書目詳細資料
發表在:Br J Pharmacol
Main Authors: Josephs, Tracy M., Keller, Andrew N., Khajehali, Elham, DeBono, Aaron, Langmead, Christopher J., Conigrave, Arthur D., Capuano, Ben, Kufareva, Irina, Gregory, Karen J., Leach, Katie
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070164/
https://ncbi.nlm.nih.gov/pubmed/31881094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14961
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