Live Respiratory Syncytial Virus Attenuated by M2-2 Deletion and Stabilized Temperature Sensitivity Mutation 1030s Is a Promising Vaccine Candidate in Children

BACKGROUND: The safety and immunogenicity of live respiratory syncytial virus (RSV) candidate vaccine, LID/ΔM2-2/1030s, with deletion of RSV ribonucleic acid synthesis regulatory protein M2-2 and genetically stabilized temperature-sensitivity mutation 1030s in the RSV polymerase protein was evaluate...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: McFarland, Elizabeth J, Karron, Ruth A, Muresan, Petronella, Cunningham, Coleen K, Libous, Jennifer, Perlowski, Charlotte, Thumar, Bhagvanji, Gnanashanmugam, Devasena, Moye, Jack, Schappell, Elizabeth, Barr, Emily, Rexroad, Vivian, Fearn, Laura, Spector, Stephen A, Aziz, Mariam, Cielo, Mikhaela, Beneri, Christy, Wiznia, Andrew, Luongo, Cindy, Collins, Peter, Buchholz, Ursula J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996856/
https://ncbi.nlm.nih.gov/pubmed/31758177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz603
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