Live Respiratory Syncytial Virus (RSV) Vaccine Candidate Containing Stabilized Temperature-Sensitivity Mutations Is Highly Attenuated in RSV-Seronegative Infants and Children

BACKGROUND: Respiratory syncytial virus (RSV) is the most important viral cause of severe respiratory illness in young children and lacks a vaccine. RSV cold-passage/stabilized 2 (RSVcps2) is a modification of a previously evaluated vaccine candidate in which 2 major attenuating mutations have been...

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Dettagli Bibliografici
Pubblicato in:J Infect Dis
Autori principali: Buchholz, Ursula J, Cunningham, Coleen K, Muresan, Petronella, Gnanashanmugam, Devasena, Sato, Paul, Siberry, George K, Rexroad, Vivian, Valentine, Megan, Perlowski, Charlotte, Schappell, Elizabeth, Thumar, Bhagvinji, Luongo, Cindy, Barr, Emily, Aziz, Mariam, Yogev, Ram, Spector, Stephen A, Collins, Peter L, McFarland, Elizabeth J, Karron, Ruth A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894088/
https://ncbi.nlm.nih.gov/pubmed/29509929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy066
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