Live Respiratory Syncytial Virus (RSV) Vaccine Candidate Containing Stabilized Temperature-Sensitivity Mutations Is Highly Attenuated in RSV-Seronegative Infants and Children

BACKGROUND: Respiratory syncytial virus (RSV) is the most important viral cause of severe respiratory illness in young children and lacks a vaccine. RSV cold-passage/stabilized 2 (RSVcps2) is a modification of a previously evaluated vaccine candidate in which 2 major attenuating mutations have been...

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Bibliografische gegevens
Gepubliceerd in:J Infect Dis
Hoofdauteurs: Buchholz, Ursula J, Cunningham, Coleen K, Muresan, Petronella, Gnanashanmugam, Devasena, Sato, Paul, Siberry, George K, Rexroad, Vivian, Valentine, Megan, Perlowski, Charlotte, Schappell, Elizabeth, Thumar, Bhagvinji, Luongo, Cindy, Barr, Emily, Aziz, Mariam, Yogev, Ram, Spector, Stephen A, Collins, Peter L, McFarland, Elizabeth J, Karron, Ruth A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
Onderwerpen:
Major Articles and Brief Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894088/
https://ncbi.nlm.nih.gov/pubmed/29509929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy066
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