Live Respiratory Syncytial Virus (RSV) Vaccine Candidate Containing Stabilized Temperature-Sensitivity Mutations Is Highly Attenuated in RSV-Seronegative Infants and Children

BACKGROUND: Respiratory syncytial virus (RSV) is the most important viral cause of severe respiratory illness in young children and lacks a vaccine. RSV cold-passage/stabilized 2 (RSVcps2) is a modification of a previously evaluated vaccine candidate in which 2 major attenuating mutations have been...

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Dades bibliogràfiques
Publicat a:J Infect Dis
Autors principals: Buchholz, Ursula J, Cunningham, Coleen K, Muresan, Petronella, Gnanashanmugam, Devasena, Sato, Paul, Siberry, George K, Rexroad, Vivian, Valentine, Megan, Perlowski, Charlotte, Schappell, Elizabeth, Thumar, Bhagvinji, Luongo, Cindy, Barr, Emily, Aziz, Mariam, Yogev, Ram, Spector, Stephen A, Collins, Peter L, McFarland, Elizabeth J, Karron, Ruth A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894088/
https://ncbi.nlm.nih.gov/pubmed/29509929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy066
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