Live Respiratory Syncytial Virus (RSV) Vaccine Candidate Containing Stabilized Temperature-Sensitivity Mutations Is Highly Attenuated in RSV-Seronegative Infants and Children

BACKGROUND: Respiratory syncytial virus (RSV) is the most important viral cause of severe respiratory illness in young children and lacks a vaccine. RSV cold-passage/stabilized 2 (RSVcps2) is a modification of a previously evaluated vaccine candidate in which 2 major attenuating mutations have been...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Infect Dis
Κύριοι συγγραφείς: Buchholz, Ursula J, Cunningham, Coleen K, Muresan, Petronella, Gnanashanmugam, Devasena, Sato, Paul, Siberry, George K, Rexroad, Vivian, Valentine, Megan, Perlowski, Charlotte, Schappell, Elizabeth, Thumar, Bhagvinji, Luongo, Cindy, Barr, Emily, Aziz, Mariam, Yogev, Ram, Spector, Stephen A, Collins, Peter L, McFarland, Elizabeth J, Karron, Ruth A
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2018
Θέματα:
Major Articles and Brief Reports
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894088/
https://ncbi.nlm.nih.gov/pubmed/29509929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy066
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