Live Respiratory Syncytial Virus Attenuated by M2-2 Deletion and Stabilized Temperature Sensitivity Mutation 1030s Is a Promising Vaccine Candidate in Children

BACKGROUND: The safety and immunogenicity of live respiratory syncytial virus (RSV) candidate vaccine, LID/ΔM2-2/1030s, with deletion of RSV ribonucleic acid synthesis regulatory protein M2-2 and genetically stabilized temperature-sensitivity mutation 1030s in the RSV polymerase protein was evaluate...

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Gepubliceerd in:J Infect Dis
Hoofdauteurs: McFarland, Elizabeth J, Karron, Ruth A, Muresan, Petronella, Cunningham, Coleen K, Libous, Jennifer, Perlowski, Charlotte, Thumar, Bhagvanji, Gnanashanmugam, Devasena, Moye, Jack, Schappell, Elizabeth, Barr, Emily, Rexroad, Vivian, Fearn, Laura, Spector, Stephen A, Aziz, Mariam, Cielo, Mikhaela, Beneri, Christy, Wiznia, Andrew, Luongo, Cindy, Collins, Peter, Buchholz, Ursula J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Major Articles and Brief Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996856/
https://ncbi.nlm.nih.gov/pubmed/31758177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiz603
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