Live-Attenuated Respiratory Syncytial Virus Vaccine With M2-2 Deletion and With Small Hydrophobic Noncoding Region Is Highly Immunogenic in Children

BACKGROUND: Respiratory syncytial virus (RSV) is the leading viral cause of severe pediatric respiratory illness, and vaccines are needed. Live RSV vaccine D46/NS2/N/ΔM2-2-HindIII, attenuated by deletion of the RSV RNA regulatory protein M2-2, is based on previous candidate LID/ΔM2-2 but incorporate...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: McFarland, Elizabeth J, Karron, Ruth A, Muresan, Petronella, Cunningham, Coleen K, Perlowski, Charlotte, Libous, Jennifer, Oliva, Jennifer, Jean-Philippe, Patrick, Moye, Jack, Schappell, Elizabeth, Barr, Emily, Rexroad, Vivian, Fearn, Laura, Cielo, Mikhaela, Wiznia, Andrew, Deville, Jaime G, Yang, Lijuan, Luongo, Cindy, Collins, Peter L, Buchholz, Ursula J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289559/
https://ncbi.nlm.nih.gov/pubmed/32006006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiaa049
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