Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in Children

BACKGROUND: Live respiratory syncytial virus (RSV) candidate vaccine LIDΔM2-2 is attenuated by deletion of the RSV RNA regulatory protein M2-2, resulting in upregulated viral gene transcription and antigen expression but reduced RNA replication. METHODS: RSV-seronegative children ages 6–24 months re...

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Bibliographic Details
Published in:J Infect Dis
Main Authors: McFarland, Elizabeth J, Karron, Ruth A, Muresan, Petronella, Cunningham, Coleen K, Valentine, Megan E, Perlowski, Charlotte, Thumar, Bhagvanji, Gnanashanmugam, Devasena, Siberry, George K, Schappell, Elizabeth, Barr, Emily, Rexroad, Vivian, Yogev, Ram, Spector, Stephen A, Aziz, Mariam, Patel, Nehali, Cielo, Mikhaela, Luongo, Cindy, Collins, Peter L, Buchholz, Ursula J
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Major Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894092/
https://ncbi.nlm.nih.gov/pubmed/29509911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy040
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