Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in Children

BACKGROUND: Live respiratory syncytial virus (RSV) candidate vaccine LIDΔM2-2 is attenuated by deletion of the RSV RNA regulatory protein M2-2, resulting in upregulated viral gene transcription and antigen expression but reduced RNA replication. METHODS: RSV-seronegative children ages 6–24 months re...

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Veröffentlicht in:J Infect Dis
Hauptverfasser: McFarland, Elizabeth J, Karron, Ruth A, Muresan, Petronella, Cunningham, Coleen K, Valentine, Megan E, Perlowski, Charlotte, Thumar, Bhagvanji, Gnanashanmugam, Devasena, Siberry, George K, Schappell, Elizabeth, Barr, Emily, Rexroad, Vivian, Yogev, Ram, Spector, Stephen A, Aziz, Mariam, Patel, Nehali, Cielo, Mikhaela, Luongo, Cindy, Collins, Peter L, Buchholz, Ursula J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894092/
https://ncbi.nlm.nih.gov/pubmed/29509911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy040
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