Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in Children

BACKGROUND: Live respiratory syncytial virus (RSV) candidate vaccine LIDΔM2-2 is attenuated by deletion of the RSV RNA regulatory protein M2-2, resulting in upregulated viral gene transcription and antigen expression but reduced RNA replication. METHODS: RSV-seronegative children ages 6–24 months re...

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Bibliografische gegevens
Gepubliceerd in:J Infect Dis
Hoofdauteurs: McFarland, Elizabeth J, Karron, Ruth A, Muresan, Petronella, Cunningham, Coleen K, Valentine, Megan E, Perlowski, Charlotte, Thumar, Bhagvanji, Gnanashanmugam, Devasena, Siberry, George K, Schappell, Elizabeth, Barr, Emily, Rexroad, Vivian, Yogev, Ram, Spector, Stephen A, Aziz, Mariam, Patel, Nehali, Cielo, Mikhaela, Luongo, Cindy, Collins, Peter L, Buchholz, Ursula J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
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Major Articles and Brief Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894092/
https://ncbi.nlm.nih.gov/pubmed/29509911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy040
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