Live-Attenuated Respiratory Syncytial Virus Vaccine With Deletion of RNA Synthesis Regulatory Protein M2-2 and Cold Passage Mutations Is Overattenuated

BACKGROUND: The live respiratory syncytial virus (RSV) candidate vaccine LIDcpΔM2-2 is attenuated through deletion of M2-2 and 5 cold-passage mutations. METHODS: RSV-seronegative children aged 6–24 months received a single intranasal dose of 10(5) plaque-forming units (PFU) of LIDcpΔM2-2 or placebo....

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Библиографические подробности
Опубликовано в: :Open Forum Infect Dis
Главные авторы: Cunningham, Coleen K, Karron, Ruth, Muresan, Petronella, McFarland, Elizabeth J, Perlowski, Charlotte, Libous, Jennifer, Thumar, Bhagvanji, Gnanashanmugam, Devasena, Moye, Jack, Schappell, Elizabeth, Barr, Emily, Rexroad, Vivian, Aziz, Mariam, Deville, Jaime, Rutstein, Richard, Yang, Lijuan, Luongo, Cindy, Collins, Peter, Buchholz, Ursula
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Brief Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559275/
https://ncbi.nlm.nih.gov/pubmed/31211158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz212
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