Live-Attenuated Respiratory Syncytial Virus Vaccine With Deletion of RNA Synthesis Regulatory Protein M2-2 and Cold Passage Mutations Is Overattenuated

BACKGROUND: The live respiratory syncytial virus (RSV) candidate vaccine LIDcpΔM2-2 is attenuated through deletion of M2-2 and 5 cold-passage mutations. METHODS: RSV-seronegative children aged 6–24 months received a single intranasal dose of 10(5) plaque-forming units (PFU) of LIDcpΔM2-2 or placebo....

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Open Forum Infect Dis
मुख्य लेखकों: Cunningham, Coleen K, Karron, Ruth, Muresan, Petronella, McFarland, Elizabeth J, Perlowski, Charlotte, Libous, Jennifer, Thumar, Bhagvanji, Gnanashanmugam, Devasena, Moye, Jack, Schappell, Elizabeth, Barr, Emily, Rexroad, Vivian, Aziz, Mariam, Deville, Jaime, Rutstein, Richard, Yang, Lijuan, Luongo, Cindy, Collins, Peter, Buchholz, Ursula
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2019
विषय:
Brief Report
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559275/
https://ncbi.nlm.nih.gov/pubmed/31211158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz212
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