Live-Attenuated Respiratory Syncytial Virus Vaccine With Deletion of RNA Synthesis Regulatory Protein M2-2 and Cold Passage Mutations Is Overattenuated

BACKGROUND: The live respiratory syncytial virus (RSV) candidate vaccine LIDcpΔM2-2 is attenuated through deletion of M2-2 and 5 cold-passage mutations. METHODS: RSV-seronegative children aged 6–24 months received a single intranasal dose of 10(5) plaque-forming units (PFU) of LIDcpΔM2-2 or placebo....

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Bibliografiske detaljer
Udgivet i:Open Forum Infect Dis
Main Authors: Cunningham, Coleen K, Karron, Ruth, Muresan, Petronella, McFarland, Elizabeth J, Perlowski, Charlotte, Libous, Jennifer, Thumar, Bhagvanji, Gnanashanmugam, Devasena, Moye, Jack, Schappell, Elizabeth, Barr, Emily, Rexroad, Vivian, Aziz, Mariam, Deville, Jaime, Rutstein, Richard, Yang, Lijuan, Luongo, Cindy, Collins, Peter, Buchholz, Ursula
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6559275/
https://ncbi.nlm.nih.gov/pubmed/31211158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz212
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