ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942

The CDK7 inhibitors (CDK7i) ICEC0942 and THZ1, are promising new cancer therapeutics. Resistance to targeted drugs frequently compromises cancer treatment. We sought to identify mechanisms by which cancer cells may become resistant to CDK7i. Resistant lines were established through continuous drug s...

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發表在:Oncogene
Main Authors: Sava, Georgina P., Fan, Hailing, Fisher, Rosemary A., Lusvarghi, Sabrina, Pancholi, Sunil, Ambudkar, Suresh V., Martin, Lesley-Ann, Charles Coombes, R., Buluwela, Lakjaya, Ali, Simak
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962093/
https://ncbi.nlm.nih.gov/pubmed/31530935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1008-y
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