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2.5 Å-resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942
The human CDK-activating kinase (CAK), composed of CDK7, cyclin H, and MAT1, is involved in the control of transcription initiation and the cell cycle. Because of these activities, it has been identified as a promising target for cancer chemotherapy. A number of CDK7 inhibitors have entered clinical...
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| Publicado no: | Biophys J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7896097/ https://ncbi.nlm.nih.gov/pubmed/33476598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.12.030 |
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