ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for transcription, and acts by phosphorylating the C-t...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Patel, Hetal, Periyasamy, Manikandan, Sava, Georgina P., Bondke, Alexander, Slafer, Brian W., Kroll, Sebastian H. B., Barbazanges, Marion, Starkey, Richard, Ottaviani, Silvia, Harrod, Alison, Aboagye, Eric O., Buluwela, Laki, Fuchter, Matthew J., Barrett, Anthony G. M., Coombes, Charles, Ali, Simak
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985928/
https://ncbi.nlm.nih.gov/pubmed/29545334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0847
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