ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for transcription, and acts by phosphorylating the C-t...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Patel, Hetal, Periyasamy, Manikandan, Sava, Georgina P., Bondke, Alexander, Slafer, Brian W., Kroll, Sebastian H. B., Barbazanges, Marion, Starkey, Richard, Ottaviani, Silvia, Harrod, Alison, Aboagye, Eric O., Buluwela, Laki, Fuchter, Matthew J., Barrett, Anthony G. M., Coombes, Charles, Ali, Simak
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985928/
https://ncbi.nlm.nih.gov/pubmed/29545334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0847
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