ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for transcription, and acts by phosphorylating the C-t...

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Detaylı Bibliyografya
Yayımlandı:Mol Cancer Ther
Asıl Yazarlar: Patel, Hetal, Periyasamy, Manikandan, Sava, Georgina P., Bondke, Alexander, Slafer, Brian W., Kroll, Sebastian H. B., Barbazanges, Marion, Starkey, Richard, Ottaviani, Silvia, Harrod, Alison, Aboagye, Eric O., Buluwela, Laki, Fuchter, Matthew J., Barrett, Anthony G. M., Coombes, Charles, Ali, Simak
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985928/
https://ncbi.nlm.nih.gov/pubmed/29545334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0847
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