ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment

Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for transcription, and acts by phosphorylating the C-t...

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Publié dans:Mol Cancer Ther
Auteurs principaux: Patel, Hetal, Periyasamy, Manikandan, Sava, Georgina P., Bondke, Alexander, Slafer, Brian W., Kroll, Sebastian H. B., Barbazanges, Marion, Starkey, Richard, Ottaviani, Silvia, Harrod, Alison, Aboagye, Eric O., Buluwela, Laki, Fuchter, Matthew J., Barrett, Anthony G. M., Coombes, Charles, Ali, Simak
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985928/
https://ncbi.nlm.nih.gov/pubmed/29545334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0847
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