Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor–Positive Breast Cancer

PURPOSE: CDK-activating kinase (CAK) is required for the regulation of the cell cycle and is a trimeric complex consisting of cyclin-dependent kinase 7 (CDK7), Cyclin H, and the accessory protein, MAT1. CDK7 also plays a critical role in regulating transcription, primarily by phosphorylating RNA pol...

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Xehetasun bibliografikoak
Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Patel, Hetal, Abduljabbar, Rezvan, Lai, Chun-Fui, Periyasamy, Manikandan, Harrod, Alison, Gemma, Carolina, Steel, Jennifer H., Patel, Naina, Busonero, Claudia, Jerjees, Dena, Remenyi, Judit, Smith, Sally, Gomm, Jennifer J., Magnani, Luca, Győrffy, Balázs, Jones, Louise J., Fuller-Pace, Frances, Shousha, Sami, Buluwela, Laki, Rakha, Emad A., Ellis, Ian O., Coombes, R. Charles, Ali, Simak
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293170/
https://ncbi.nlm.nih.gov/pubmed/27301701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1104
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