Induction of the TEAD Co-activator VGLL1 by Estrogen Receptor-Targeted Therapy Drives Resistance in Breast Cancer

Resistance to endocrine therapies (ET) is common in estrogen receptor (ER) positive breast cancer, and most relapsed patients die with ET-resistant disease. While genetic mutations provide explanations for some relapses, mechanisms of resistance remain undefined in many cases. Drug-induced epigeneti...

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Publicado no:Cancer Res
Main Authors: Gemma, Carolina, Lai, Chun-Fui, Singh, Anup K, Belfiore, Antonino, Portman, Neil, Milioli, Heloisa Z, Periyasamy, Manikandan, Raafat, Sara, Nicholls, Alyssa J., Davies, Claire M, Patel, Naina R., Simmons, Georgia M., Fan, Hailing, Nguyen, Van T M, Magnani, Luca, Rakha, Emad, Martin, Lesley-Ann, Lim, Elgene, Coombes, R. Charles, Pruneri, Giancarlo, Buluwela, Laki, Ali, Simak
Formato: Artigo
Idioma:Inglês
Publicado em: 2024
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616691/
https://ncbi.nlm.nih.gov/pubmed/39356622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-24-0013
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