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VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription
VGLL4 has been identified as a YAP inhibitor. However, the exact function of VGLL4 in bone development and bone homeostasis remains unclear. In this study, we demonstrated that VGLL4 breaks TEADs-mediated transcriptional inhibition of RUNX2 to promote osteoblast differentiation and bone development....
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7608831/ https://ncbi.nlm.nih.gov/pubmed/33097532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba4147 |
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