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VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcription

VGLL4 has been identified as a YAP inhibitor. However, the exact function of VGLL4 in bone development and bone homeostasis remains unclear. In this study, we demonstrated that VGLL4 breaks TEADs-mediated transcriptional inhibition of RUNX2 to promote osteoblast differentiation and bone development....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Suo, Jinlong, Feng, Xue, Li, Jiayi, Wang, Jinghui, Wang, Zuoyun, Zhang, Lei, Zou, Weiguo
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608831/
https://ncbi.nlm.nih.gov/pubmed/33097532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba4147
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