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2.5 Å-resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942

The human CDK-activating kinase (CAK), composed of CDK7, cyclin H, and MAT1, is involved in the control of transcription initiation and the cell cycle. Because of these activities, it has been identified as a promising target for cancer chemotherapy. A number of CDK7 inhibitors have entered clinical...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Biophys J
मुख्य लेखकों: Greber, Basil J., Remis, Jonathan, Ali, Simak, Nogales, Eva
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Biophysical Society 2021
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896097/
https://ncbi.nlm.nih.gov/pubmed/33476598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.12.030
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