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ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators
P-glycoprotein (P-gp), an ABC transporter associated with multidrug resistance in cancer cells, is capable of effluxing a number of xenobiotics as well as anticancer drugs. The transport of molecules through the transmembrane region of P-gp involves orchestrated conformational changes between inward...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Biochem J |
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| Κύριοι συγγραφείς: | , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7404625/ https://ncbi.nlm.nih.gov/pubmed/31774117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190736 |
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