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ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators

P-glycoprotein (P-gp), an ABC transporter associated with multidrug resistance in cancer cells, is capable of effluxing a number of xenobiotics as well as anticancer drugs. The transport of molecules through the transmembrane region of P-gp involves orchestrated conformational changes between inward...

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Bibliografske podrobnosti
izdano v:Biochem J
Main Authors: Lusvarghi, Sabrina, Ambudkar, Suresh V.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404625/
https://ncbi.nlm.nih.gov/pubmed/31774117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190736
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