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ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators
P-glycoprotein (P-gp), an ABC transporter associated with multidrug resistance in cancer cells, is capable of effluxing a number of xenobiotics as well as anticancer drugs. The transport of molecules through the transmembrane region of P-gp involves orchestrated conformational changes between inward...
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| Gepubliceerd in: | Biochem J |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7404625/ https://ncbi.nlm.nih.gov/pubmed/31774117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190736 |
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