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Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer
Fluorouracil (5-FU) remains a first-line chemotherapeutic agent for colorectal cancer (CRC). However, a subset of CRC patients who have defective mismatch repair (dMMR) pathway show resistance to 5-FU. Here, we demonstrate that the efficacy of 5-FU in dMMR CRC cells is largely dependent on the DNA b...
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| Publicado en: | Mol Cancer Ther |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6946866/ https://ncbi.nlm.nih.gov/pubmed/31575655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0600 |
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