Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer

Fluorouracil (5-FU) remains a first-line chemotherapeutic agent for colorectal cancer (CRC). However, a subset of CRC patients who have defective mismatch repair (dMMR) pathway show resistance to 5-FU. Here, we demonstrate that the efficacy of 5-FU in dMMR CRC cells is largely dependent on the DNA b...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Song, Heyu, Zeng, Jiping, Roychoudhury, Shrabasti, Biswas, Pranjal, Mohapatra, Bhopal, Ray, Sutapa, Dowlatshahi, Kayvon, Wang, Jing, Band, Vimla, Talmon, Geoffrey, Bhakat, Kishor K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6946866/
https://ncbi.nlm.nih.gov/pubmed/31575655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0600
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