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Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair

Apurinic/apyrimidinic (AP) sites are frequently generated in the genome by spontaneous depurination/depyrimidination or after removal of oxidized/modified bases by DNA glycosylases during the base excision repair (BER) pathway. Unrepaired AP sites are mutagenic and block DNA replication and transcri...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Sengupta, Shiladitya, Mantha, Anil K., Song, Heyu, Roychoudhury, Shrabasti, Nath, Somsubhra, Ray, Sutapa, Bhakat, Kishor K.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342734/
https://ncbi.nlm.nih.gov/pubmed/27655688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12113
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