Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation

Mammalian apurinic/apyrimidinic (AP) endonuclease 1 (APE1), a ubiquitous and multifunctional protein, plays an essential role in the repair of both endogenous and drug-induced DNA damages in the genome. Unlike its E.coli counterpart Xth, mammalian APE1 has a unique N-terminal domain and possesses bo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bhakat, Kishor K., Sengupta, Shiladitya, Adeniyi, Victor F., Roychoudhury, Shrabasti, Nath, Somsubhra, Bellot, Larry J., Feng, Dan, Mantha, Anil K., Sinha, Mala, Qiu, Suimin, Luxon, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008384/
https://ncbi.nlm.nih.gov/pubmed/26981776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8026
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