Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

Apurinic/apyrimidinic (AP) sites, the most frequently formed DNA lesions in the genome, inhibit transcription and block replication. The primary enzyme that repairs AP sites in mammalian cells is the AP endonuclease (APE1), which functions through the base excision repair (BER) pathway. Although the...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Roychoudhury, Shrabasti, Nath, Somsubhra, Song, Heyu, Hegde, Muralidhar L., Bellot, Larry J., Mantha, Anil K., Sengupta, Shiladitya, Ray, Sutapa, Natarajan, Amarnath, Bhakat, Kishor K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335514/
https://ncbi.nlm.nih.gov/pubmed/27994014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00401-16
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