Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

Apurinic/apyrimidinic (AP) sites, the most frequently formed DNA lesions in the genome, inhibit transcription and block replication. The primary enzyme that repairs AP sites in mammalian cells is the AP endonuclease (APE1), which functions through the base excision repair (BER) pathway. Although the...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Cell Biol
Κύριοι συγγραφείς: Roychoudhury, Shrabasti, Nath, Somsubhra, Song, Heyu, Hegde, Muralidhar L., Bellot, Larry J., Mantha, Anil K., Sengupta, Shiladitya, Ray, Sutapa, Natarajan, Amarnath, Bhakat, Kishor K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2017
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335514/
https://ncbi.nlm.nih.gov/pubmed/27994014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00401-16
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