Loss of NQO1 generates genotoxic estrogen-DNA adducts in Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Corneal Dystrophy (FECD) is an age-related genetically complex disease characterized by increased oxidative DNA damage and progressive degeneration of corneal endothelial cells (HCEnCs). FECD has a greater incidence and advanced phenotype in women, suggesting a possible role of hor...

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Publicado en:Free Radic Biol Med
Autores principales: Miyajima, Taiga, Melangath, Geetha, Zhu, Shan, Deshpande, Neha, Vasanth, Shivakumar, Mondal, Bodhisattwa, Kumar, Varun, Chen, Yuming, Price, Marianne, Price, Francis, Rogan, Eleanor G., Zahid, Muhammad, Jurkunas, Ula
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939626/
https://ncbi.nlm.nih.gov/pubmed/31857234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.12.014
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