Activation of PINK1-Parkin–Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy

Corneal endothelium (CE) is a monolayer of mitochondria-rich cells, critical for maintaining corneal transparency compatible with clear vision. Fuchs endothelial corneal dystrophy (FECD) is a heterogeneous, genetically complex disorder, where oxidative stress plays a key role in the rosette formatio...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Miyai, Takashi, Vasanth, Shivakumar, Melangath, Geetha, Deshpande, Neha, Kumar, Varun, Benischke, Anne-Sophie, Chen, Yuming, Price, Marianne O., Price, Francis W., Jurkunas, Ula V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892225/
https://ncbi.nlm.nih.gov/pubmed/31361992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.06.012
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