Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy

Human corneal endothelial cells (HCEnCs) are terminally differentiated cells that have limited regenerative potential. The large numbers of mitochondria in HCEnCs are critical for pump and barrier function required for corneal hydration and transparency. Fuchs Endothelial Corneal Dystrophy (FECD) is...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Benischke, Anne-Sophie, Vasanth, Shivakumar, Miyai, Takashi, Katikireddy, Kishore Reddy, White, Tomas, Chen, Yuming, Halilovic, Adna, Price, Marianne, Price, Francis, Liton, Paloma B., Jurkunas, Ula V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532298/
https://ncbi.nlm.nih.gov/pubmed/28751712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06523-2
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