Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy

Human corneal endothelial cells (HCEnCs) are terminally differentiated cells that have limited regenerative potential. The large numbers of mitochondria in HCEnCs are critical for pump and barrier function required for corneal hydration and transparency. Fuchs Endothelial Corneal Dystrophy (FECD) is...

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Pubblicato in:Sci Rep
Autori principali: Benischke, Anne-Sophie, Vasanth, Shivakumar, Miyai, Takashi, Katikireddy, Kishore Reddy, White, Tomas, Chen, Yuming, Halilovic, Adna, Price, Marianne, Price, Francis, Liton, Paloma B., Jurkunas, Ula V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532298/
https://ncbi.nlm.nih.gov/pubmed/28751712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06523-2
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