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Cell cycle re-entry and arrest in G2/M phase induces senescence and fibrosis in Fuchs Endothelial Corneal Dystrophy

Fuchs endothelial corneal dystrophy (FECD) is an age-related disease whereby progressive loss of corneal endothelial cells (CEnCs) leads to loss of vision. There is currently a lack of therapeutic interventions as the etiology of the disease is complex, with both genetic and environmental factors. I...

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Détails bibliographiques
Publié dans:Free Radic Biol Med
Auteurs principaux: White, Tomas L., Deshpande, Neha, Kumar, Varun, Gauthier, Alex G., Jurkunas, Ula V.
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897316/
https://ncbi.nlm.nih.gov/pubmed/33418109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2020.12.445
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