Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours

Improved delivery materials are needed to enable siRNA transport across biological barriers, including the blood–brain barrier (BBB), to treat diseases like brain cancer. We engineered bioreducible nanoparticles for systemic siRNA delivery to patient-derived glioblastoma cells in an orthotopic mouse...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nanoscale
Prif Awduron: Karlsson, Johan, Rui, Yuan, Kozielski, Kristen L., Placone, Amanda L., Choi, Olivia, Tzeng, Stephany Y., Kim, Jayoung, Keyes, Jamal J., Bogorad, Max I., Gabrielson, Kathleen, Guerrero-Cazares, Hugo, Quiñones-Hinojosa, Alfredo, Searson, Peter C., Green, Jordan J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924015/
https://ncbi.nlm.nih.gov/pubmed/31612183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9nr04795f
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