Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours

Improved delivery materials are needed to enable siRNA transport across biological barriers, including the blood–brain barrier (BBB), to treat diseases like brain cancer. We engineered bioreducible nanoparticles for systemic siRNA delivery to patient-derived glioblastoma cells in an orthotopic mouse...

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Detalhes bibliográficos
Publicado no:Nanoscale
Main Authors: Karlsson, Johan, Rui, Yuan, Kozielski, Kristen L., Placone, Amanda L., Choi, Olivia, Tzeng, Stephany Y., Kim, Jayoung, Keyes, Jamal J., Bogorad, Max I., Gabrielson, Kathleen, Guerrero-Cazares, Hugo, Quiñones-Hinojosa, Alfredo, Searson, Peter C., Green, Jordan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6924015/
https://ncbi.nlm.nih.gov/pubmed/31612183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9nr04795f
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