Bioreducible Cationic Polymer-Based Nanoparticles for Efficient and Environmentally Triggered Cytoplasmic siRNA Delivery to Primary Human Brain Cancer Cells

[Image: see text] siRNA nanomedicines can potentially treat many human diseases, but safe and effective delivery remains a challenge. DNA delivery polymers such as poly(β-amino ester)s (PBAEs) generally cannot effectively deliver siRNA and require chemical modification to enable siRNA encapsulation...

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Autors principals: Kozielski, Kristen L., Tzeng, Stephany Y., Hurtado De Mendoza, Bolivia A., Green, Jordan J.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004313/
https://ncbi.nlm.nih.gov/pubmed/24673565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn500704t
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