A novel mitochondrial inhibitor blocks MAPK pathway and overcomes MAPK inhibitor–resistance in melanoma.

PURPOSE: To determine if inhibition of mitochondrial oxidative phosphorylation (OxPhos) is an effective strategy against MAPK pathway inhibitor (MAPKi)-resistant BRAF-mutant melanomas. EXPERIMENTAL DESIGN: The anti-melanoma activity of IACS-010759 (OPi), a novel OxPhos complex I inhibitor, was evalu...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Vashisht Gopal, Y. N., Gammon, Seth, Prasad, Rishika, Knighton, Barbara, Pisaneschi, Federica, Roszik, Jason, Feng, Ningping, Johnson, Sarah, Pramanik, Snigdha, Sudderth, Jessica, Sui, Dawen, Hudgens, Courtney, Fischer, Grant M., Deng, Wanleng, Reuben, Alexandre, Peng, Weiyi, Wang, Jian, McQuade, Jennifer L., Tetzlaff, Michael T., Di Francesco, Maria E., Marszalek, Joe, Piwnica-Worms, David, DeBerardinis, Ralph J., Davies, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825560/
https://ncbi.nlm.nih.gov/pubmed/31439581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0836
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