A novel mitochondrial inhibitor blocks MAPK pathway and overcomes MAPK inhibitor–resistance in melanoma.

PURPOSE: To determine if inhibition of mitochondrial oxidative phosphorylation (OxPhos) is an effective strategy against MAPK pathway inhibitor (MAPKi)-resistant BRAF-mutant melanomas. EXPERIMENTAL DESIGN: The anti-melanoma activity of IACS-010759 (OPi), a novel OxPhos complex I inhibitor, was evalu...

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Publicado no:Clin Cancer Res
Main Authors: Vashisht Gopal, Y. N., Gammon, Seth, Prasad, Rishika, Knighton, Barbara, Pisaneschi, Federica, Roszik, Jason, Feng, Ningping, Johnson, Sarah, Pramanik, Snigdha, Sudderth, Jessica, Sui, Dawen, Hudgens, Courtney, Fischer, Grant M., Deng, Wanleng, Reuben, Alexandre, Peng, Weiyi, Wang, Jian, McQuade, Jennifer L., Tetzlaff, Michael T., Di Francesco, Maria E., Marszalek, Joe, Piwnica-Worms, David, DeBerardinis, Ralph J., Davies, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825560/
https://ncbi.nlm.nih.gov/pubmed/31439581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0836
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