A novel mitochondrial inhibitor blocks MAPK pathway and overcomes MAPK inhibitor–resistance in melanoma.

PURPOSE: To determine if inhibition of mitochondrial oxidative phosphorylation (OxPhos) is an effective strategy against MAPK pathway inhibitor (MAPKi)-resistant BRAF-mutant melanomas. EXPERIMENTAL DESIGN: The anti-melanoma activity of IACS-010759 (OPi), a novel OxPhos complex I inhibitor, was evalu...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Vashisht Gopal, Y. N., Gammon, Seth, Prasad, Rishika, Knighton, Barbara, Pisaneschi, Federica, Roszik, Jason, Feng, Ningping, Johnson, Sarah, Pramanik, Snigdha, Sudderth, Jessica, Sui, Dawen, Hudgens, Courtney, Fischer, Grant M., Deng, Wanleng, Reuben, Alexandre, Peng, Weiyi, Wang, Jian, McQuade, Jennifer L., Tetzlaff, Michael T., Di Francesco, Maria E., Marszalek, Joe, Piwnica-Worms, David, DeBerardinis, Ralph J., Davies, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825560/
https://ncbi.nlm.nih.gov/pubmed/31439581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0836
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