Novel derivatives of anaplastic lymphoma kinase inhibitors: Synthesis, radiolabeling, and preliminary biological studies of fluoroethyl analogues of crizotinib, alectinib, and ceritinib

Anaplastic lymphoma kinase (ALK), an oncogenic receptor tyrosine kinase, is a therapeutic target in various cancers, including non-small cell lung cancer. Although several ALK inhibitors, including crizotinib, ceritinib, and alectinib, are approved for cancer treatment, their long-term benefit is of...

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Bibliografiske detaljer
Udgivet i:Eur J Med Chem
Main Authors: Radaram, Bhasker, Pisaneschi, Federica, Rao, Yi, Yang, Ping, Piwnica-Worms, David, Alauddin, Mian M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7193943/
https://ncbi.nlm.nih.gov/pubmed/31425908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.111571
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