Clinical, molecular, metabolic, and immune features associated with oxidative phosphorylation in melanoma brain metastases

BACKGROUND: Recently, we showed that melanoma brain metastases (MBMs) are characterized by increased utilization of the oxidative phosphorylation (OXPHOS) metabolic pathway compared to melanoma extracranial metastases (ECMs). MBM growth was inhibited by a potent direct OXPHOS inhibitor, but observed...

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Veröffentlicht in:Neurooncol Adv
Hauptverfasser: Fischer, Grant M, Guerrieri, Renato A, Hu, Qianghua, Joon, Aron Y, Kumar, Swaminathan, Haydu, Lauren E, McQuade, Jennifer L, Vashisht Gopal, Y N, Knighton, Barbara, Deng, Wanleng, Hudgens, Courtney W, Lazar, Alexander J, Tetzlaff, Michael T, Davies, Michael A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865080/
https://ncbi.nlm.nih.gov/pubmed/33575655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa177
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