Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

There is a critical need to improve our understanding of the pathogenesis of melanoma brain metastases (MBMs). Thus, we performed RNA-sequencing (RNA-seq) on 88 resected MBMs and 42 patient-matched extracranial metastases (ECMs); tumors with sufficient tissue also underwent whole exome sequencing, T...

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Pubblicato in:Cancer Discov
Autori principali: Fischer, Grant M., Jalali, Ali, Kircher, David A., Lee, Won-Chul, McQuade, Jennifer L., Haydu, Lauren E., Joon, Aron Y., Reuben, Alexandre, de Macedo, Mariana P., Carapeto, Fernando C. L., Yang, Chendong, Srivastava, Anuj, Ambati, Chandrashekar R., Sreekumar, Arun, Hudgens, Courtney W., Knighton, Barbara, Deng, Wanleng, Ferguson, Sherise D., Tawbi, Hussein A., Glitza, Isabella C., Gershenwald, Jeffrey E., Gopal, Y. N. Vashisht, Hwu, Patrick, Huse, Jason T., Wargo, Jennifer A., Futreal, P. Andrew, Putluri, Nagireddy, Lazar, Alexander J., DeBerardinis, Ralph J., Marszalek, Joseph R., Zhang, Jianjun, Holmen, Sheri L., Tetzlaff, Michael T., Davies, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497554/
https://ncbi.nlm.nih.gov/pubmed/30787016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1489
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