Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

There is a critical need to improve our understanding of the pathogenesis of melanoma brain metastases (MBMs). Thus, we performed RNA-sequencing (RNA-seq) on 88 resected MBMs and 42 patient-matched extracranial metastases (ECMs); tumors with sufficient tissue also underwent whole exome sequencing, T...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Fischer, Grant M., Jalali, Ali, Kircher, David A., Lee, Won-Chul, McQuade, Jennifer L., Haydu, Lauren E., Joon, Aron Y., Reuben, Alexandre, de Macedo, Mariana P., Carapeto, Fernando C. L., Yang, Chendong, Srivastava, Anuj, Ambati, Chandrashekar R., Sreekumar, Arun, Hudgens, Courtney W., Knighton, Barbara, Deng, Wanleng, Ferguson, Sherise D., Tawbi, Hussein A., Glitza, Isabella C., Gershenwald, Jeffrey E., Gopal, Y. N. Vashisht, Hwu, Patrick, Huse, Jason T., Wargo, Jennifer A., Futreal, P. Andrew, Putluri, Nagireddy, Lazar, Alexander J., DeBerardinis, Ralph J., Marszalek, Joseph R., Zhang, Jianjun, Holmen, Sheri L., Tetzlaff, Michael T., Davies, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497554/
https://ncbi.nlm.nih.gov/pubmed/30787016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1489
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