Molecular Profiling Reveals Unique Immune and Metabolic Features of Melanoma Brain Metastases

There is a critical need to improve our understanding of the pathogenesis of melanoma brain metastases (MBMs). Thus, we performed RNA-sequencing (RNA-seq) on 88 resected MBMs and 42 patient-matched extracranial metastases (ECMs); tumors with sufficient tissue also underwent whole exome sequencing, T...

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Publicat a:Cancer Discov
Autors principals: Fischer, Grant M., Jalali, Ali, Kircher, David A., Lee, Won-Chul, McQuade, Jennifer L., Haydu, Lauren E., Joon, Aron Y., Reuben, Alexandre, de Macedo, Mariana P., Carapeto, Fernando C. L., Yang, Chendong, Srivastava, Anuj, Ambati, Chandrashekar R., Sreekumar, Arun, Hudgens, Courtney W., Knighton, Barbara, Deng, Wanleng, Ferguson, Sherise D., Tawbi, Hussein A., Glitza, Isabella C., Gershenwald, Jeffrey E., Gopal, Y. N. Vashisht, Hwu, Patrick, Huse, Jason T., Wargo, Jennifer A., Futreal, P. Andrew, Putluri, Nagireddy, Lazar, Alexander J., DeBerardinis, Ralph J., Marszalek, Joseph R., Zhang, Jianjun, Holmen, Sheri L., Tetzlaff, Michael T., Davies, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497554/
https://ncbi.nlm.nih.gov/pubmed/30787016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1489
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