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Counteracting oxidative phosphorylation-mediated resistance of melanomas to MAPK pathway inhibition
Mitochondrial oxidative phosphorylation (OxPhos) induces resistance to MAPK pathway inhibitors in melanoma. However, therapeutic targeting of mitochondria is challenging. In a recent study, we showed that inhibition of mTOR kinase activity resensitized resistant melanomas by indirectly inhibiting Ox...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905309/ https://ncbi.nlm.nih.gov/pubmed/27308473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723556.2014.991610 |
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