Probing the CB(1) Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist

Cannabinoid receptor 1 (CB(1)) is a potential therapeutic target for the treatment of pain, obesity and obesity-related metabolic disorders, and addiction. The crystal structure of human CB(1) has been determined in complex with the stabilizing antagonist AM6538. In the present study, we characteriz...

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Foilsithe in:Mol Pharmacol
Main Authors: Laprairie, Robert B., Vemuri, Kiran, Stahl, Edward L., Korde, Anisha, Ho, Jo-Hao, Grim, Travis W., Hua, Tian, Wu, Yiran, Stevens, Raymond C., Liu, Zhi-Jie, Makriyannis, Alexandros, Bohn, Laura M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2019
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785652/
https://ncbi.nlm.nih.gov/pubmed/31515283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.116483
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