Crystal structures of agonist-bound human cannabinoid receptor CB(1)

The cannabinoid receptor 1 (CB(1)) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ(9)-tetrahydrocannabinol (Δ(9)-THC)(1). Here we report two agonist-bound crystal structures of human CB(1) in complex with a tetrahydrocannabinol (AM11542) and a hexahydrocan...

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Publicado no:Nature
Main Authors: Hua, Tian, Vemuri, Kiran, Nikas, Spyros P., Laprairie, Robert B., Wu, Yiran, Qu, Lu, Pu, Mengchen, Korde, Anisha, Jiang, Shan, Ho, Jo-Hao, Han, Gye Won, Ding, Kang, Li, Xuanxuan, Liu, Haiguang, Hanson, Michael A., Zhao, Suwen, Bohn, Laura M., Makriyannis, Alexandros, Stevens, Raymond C., Liu, Zhi-Jie
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793864/
https://ncbi.nlm.nih.gov/pubmed/28678776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23272
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