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Probing the CB(1) Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist
Cannabinoid receptor 1 (CB(1)) is a potential therapeutic target for the treatment of pain, obesity and obesity-related metabolic disorders, and addiction. The crystal structure of human CB(1) has been determined in complex with the stabilizing antagonist AM6538. In the present study, we characteriz...
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| 出版年: | Mol Pharmacol |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6785652/ https://ncbi.nlm.nih.gov/pubmed/31515283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.116483 |
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