Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys

Nicotine, the main psychoactive component of tobacco, and (−)−Δ(9)-tetrahydrocannabinol (THC), the main psychoactive ingredient in cannabis, play major roles in tobacco and marijuana dependence as reinforcers of drug-seeking and drug-taking behavior. Drugs that act as inverse agonists of cannabinoid...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Schindler, Charles W, Redhi, Godfrey H, Vemuri, Kiran, Makriyannis, Alexandros, Le Foll, Bernard, Bergman, Jack, Goldberg, Steven R, Justinova, Zuzana
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946059/
https://ncbi.nlm.nih.gov/pubmed/26888056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2016.27
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