Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of mRNAs in most eukaryotes. Here we show that RNAs of human respiratory syncytial virus (RSV) are modified by m(6)A within discreet regions and that these modifications enhance viral replication and pathogenesis. Knockdown of...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Xue, Miaoge, Zhao, Boxuan Simen, Zhang, Zijie, Lu, Mijia, Harder, Olivia, Chen, Phylip, Lu, Zhike, Li, Anzhong, Ma, Yuanmei, Xu, Yunsheng, Liang, Xueya, Zhou, Jiyong, Niewiesk, Stefan, Peeples, Mark E., He, Chuan, Li, Jianrong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785563/
https://ncbi.nlm.nih.gov/pubmed/31597913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12504-y
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