Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of mRNAs in most eukaryotes. Here we show that RNAs of human respiratory syncytial virus (RSV) are modified by m(6)A within discreet regions and that these modifications enhance viral replication and pathogenesis. Knockdown of...

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Publicado en:Nat Commun
Autores principales: Xue, Miaoge, Zhao, Boxuan Simen, Zhang, Zijie, Lu, Mijia, Harder, Olivia, Chen, Phylip, Lu, Zhike, Li, Anzhong, Ma, Yuanmei, Xu, Yunsheng, Liang, Xueya, Zhou, Jiyong, Niewiesk, Stefan, Peeples, Mark E., He, Chuan, Li, Jianrong
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6785563/
https://ncbi.nlm.nih.gov/pubmed/31597913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12504-y
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