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Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus
N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of mRNAs in most eukaryotes. Here we show that RNAs of human respiratory syncytial virus (RSV) are modified by m(6)A within discreet regions and that these modifications enhance viral replication and pathogenesis. Knockdown of...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6785563/ https://ncbi.nlm.nih.gov/pubmed/31597913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12504-y |
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