N(6)-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

Internal N(6)-methyladenosine (m(6)A) modification is one of the most common and abundant modifications of RNA. However, the biological role(s) of viral RNA m(6)A remains elusive. Using human metapneumovirus (hMPV) as a model, we demonstrate that m(6)A serves as a molecular marker for innate immune...

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Detalhes bibliográficos
Publicado no:Nat Microbiol
Main Authors: Lu, Mijia, Zhang, Zijie, Xue, Miaoge, Zhao, Boxuan Simen, Harder, Olivia, Li, Anzhong, Liang, Xueya, Gao, Thomas Z., Xu, Yunsheng, Zhou, Jiyong, Feng, Zongdi, Niewiesk, Stefan, Peeples, Mark E., He, Chuan, Li, Jianrong
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7137398/
https://ncbi.nlm.nih.gov/pubmed/32015498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-019-0653-9
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